Amantadine 100 mg for Dogs Side Effects 2023 © Bestie Paws Hospital (2024)

Amantadine, originally developed as an antiviral agent, is recognized in veterinary medicine for its adjunctive use in managing chronic pain, particularly osteoarthritis in dogs. It works as an antagonist of the N-Methyl-D-aspartate (NMDA) receptor, a critical component in the perception of pain, providing relief from persistent discomfort.

Side Effects of Amantadine: A Closer Look

While amantadine has shown promising results in alleviating chronic pain, potential side effects need to be considered. Although generally well-tolerated, some dogs may experience certain adverse reactions to the drug.

Gastrointestinal Disturbances

Like many medications, amantadine can cause gastrointestinal issues in some dogs. Dogs might exhibit symptoms such as decreased appetite, nausea, or diarrhea. If these symptoms persist or worsen over time, it’s important to consult your veterinarian.

Neurological Effects

Amantadine has also been associated with a variety of neurological side effects. Some dogs may exhibit signs of restlessness, anxiety, or agitation. Other, more serious side effects include ataxia, disorientation, and hyperactivity.

Cardiorespiratory Concerns

Although less common, amantadine can induce cardiorespiratory side effects, including heart failure and respiratory distress. However, these are relatively rare and often associated with high doses or underlying medical conditions.

Ensuring Safe Use of Amantadine

The key to minimizing potential side effects lies in adhering to the prescribed dosage, which is usually based on the dog’s weight. Most vets recommend starting at the lower end of the dosage range and carefully monitoring the dog for any adverse reactions.

It’s also important to remember that amantadine is often used as part of a multimodal pain management approach. The drug’s effects may be altered when used in combination with other medications, such as gabapentin, tramadol, or nonsteroidal anti-inflammatory drugs (NSAIDs).

Navigating Amantadine Administration

In an effort to prevent or mitigate side effects associated with amantadine, there are several measures you can take. The drug is typically administered orally, and giving it with food may help to lessen gastrointestinal side effects. As with any new medication, you should introduce amantadine slowly, gradually increasing the dose as tolerated by your pet.

It’s worth noting that the response to amantadine can vary considerably from dog to dog. Some pets may see significant improvement in their chronic pain symptoms, while others may experience little to no benefit. Regular check-ins with your vet can ensure that the medication is producing the desired results and not causing undue discomfort.

Interactions with Other Medications

One crucial aspect of managing your pet’s medication regimen is understanding how different drugs may interact. Amantadine can interact with other medications, which may intensify or modify its effects. For instance, combining amantadine with certain drugs like tramadol or gabapentin could potentially result in enhanced pain relief, but it may also increase the likelihood of side effects.

Before starting amantadine, be sure to provide your vet with a comprehensive list of all the medications and supplements your dog is currently taking. This includes over-the-counter products and prescription medications from other vets or specialists.

Special Considerations for Senior Dogs

Age is another factor to consider when using amantadine. Elderly dogs, especially those with pre-existing renal or cardiac conditions, may be at a higher risk for developing side effects. Regular monitoring, including routine blood tests, can be helpful in these cases to promptly identify and address any potential issues.

The Role of Regular Monitoring

The importance of regular monitoring cannot be overstated when it comes to using amantadine for pain management in dogs. If your pet shows any unusual behavior or symptoms such as increased restlessness, changes in appetite, or persistent diarrhea, it’s essential to contact your vet immediately. In some cases, a dosage adjustment or change in medication may be necessary.

FAQ: Managing Side Effects of Amantadine in Dogs

Q: How soon will I notice the effects of amantadine in my dog?

The onset of action for amantadine varies from dog to dog. However, typically, it takes a few days to a week for the medication to build up in the body and exhibit noticeable effects. You may observe changes in your dog’s mobility, comfort levels, and overall behavior during this period.

Q: What should I do if my dog vomits or has diarrhea after taking amantadine?

Minor gastrointestinal issues like vomiting or diarrhea can occur as a dog’s body adjusts to amantadine. Providing the medication with food can help to mitigate these effects. If these symptoms persist or become severe, consult your vet. They may recommend altering the dosage, changing the administration method, or switching to a different medication.

Q: Can I stop giving amantadine to my dog if I notice adverse side effects?

If your dog exhibits severe or worrying side effects, contact your vet immediately. While it may be necessary to discontinue the use of amantadine, this should always be done under the guidance of a vet to prevent withdrawal symptoms or sudden worsening of your dog’s condition.

Q: My dog is on other medications. Can I still give them amantadine?

Amantadine can be given in conjunction with other medications, but it’s critical to discuss this with your vet. Certain drugs can interact with amantadine, which may either enhance or diminish its effects or cause unexpected side effects.

Q: What can I do to help my dog feel more comfortable while on amantadine?

Ensuring your dog has a comfortable and quiet space to rest can help them adjust to the medication. Additionally, maintaining a routine and keeping your dog engaged with gentle activities can help distract from any discomfort. If you notice any changes in your dog’s behavior or overall health, don’t hesitate to consult your vet.

Q: Can I adjust my dog’s dosage of amantadine if I think it’s too high or too low?

No, dosage adjustments should never be made without the express direction of your veterinarian. Changes in dosage can dramatically impact how a medication works, potentially leading to overdosing or reduced effectiveness. If you feel that the current dosage is not appropriate, it’s essential to discuss your concerns with your veterinarian.

Q: My dog seems sedated after taking amantadine. Is this normal?

A degree of sedation or lethargy can occur when a dog first starts taking amantadine. Typically, this effect diminishes as the dog’s body becomes accustomed to the medication. However, if this state of sedation persists or worsens, consult your vet right away.

Q: My dog has stopped eating since starting amantadine. What should I do?

Loss of appetite can be a side effect of amantadine, especially at the beginning of the treatment. Offering palatable, easily digestible foods may help. If your dog refuses to eat or is losing weight, contact your vet immediately. It could be a sign that the medication is not well-tolerated, and an alternative pain management strategy may be necessary.

Q: Can amantadine cause any long-term side effects in dogs?

In general, amantadine is considered safe for long-term use in dogs. However, as with any medication, it has the potential to cause side effects. Regular veterinary check-ups and monitoring your dog’s behavior and physical health are crucial when they’re on long-term medication. This helps ensure that any potential issues are detected and addressed promptly.

Q: Is amantadine suitable for all breeds of dogs?

Yes, amantadine can be used in all breeds of dogs. However, each dog is an individual, and what works well for one might not work as well for another, even of the same breed. Your vet will take into account your dog’s size, age, overall health, and specific medical conditions before prescribing amantadine or any other medication.


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Amantadine 100 mg for Dogs Side Effects 2023 © Bestie Paws Hospital (2024)


Amantadine 100 mg for Dogs Side Effects 2023 © Bestie Paws Hospital? ›

Possible side effects include agitation, soft stools, diarrhea, and gassiness. At toxic doses, side effects include tremors, anxiety, incoordination, dry mouth and vomiting. This short-acting medication should stop working within 24 hours, although effects can be longer in pets with liver or kidney disease.

What are the side effects of amantadine in dogs? ›

It is reported that some dogs may develop agitation, vomiting, flatulence, or diarrhoea (which may be watery), particularly in the early days of amantadine therapy.

How long can dogs stay on amantadine? ›

Despite this, veterinarians usually recommend giving the amantadine for two to three weeks before deciding how well it is working.

How quickly does amantadine work in dogs? ›

How long does it take for Amantadine to work in dogs? It's expected for pets to have a noticeable response to the medication after about a week, but it can take up to 3 weeks to reach its full efficacy.

Should amantadine be given with food in dogs? ›

Amantadine is given by mouth in the form of a capsule, tablet, or liquid solution. It can be given with or without food, but if your pet vomits after receiving the medication on an empty stomach, try giving it with a small meal or treat.

Which one is a serious side effect to taking amantadine? ›

Amantadine may cause some people to be agitated, irritable, or display other abnormal behaviors. It may also cause some people to have suicidal thoughts and tendencies or to become more depressed. Also tell your doctor if you have sudden or strong feelings, such as feeling nervous, angry, restless, violent, or scared.

What are the major adverse effects of amantadine? ›

dizziness, lightheadedness, fainting, or blurred vision. swelling of the hands, feet, ankles, or lower legs. difficulty urinating.

How do you know if amantadine is working? ›

If your symptoms are severe, call 911 or go to the nearest emergency room right away. How to tell if the drug is working: If you're taking amantadine for Parkinson's disease, you should have fewer tremors. You should also feel less rigid and be able to move more smoothly.

Can amantadine damage kidneys? ›

Physicians should be aware of urinary retention in patients treated with amantadine as a first sign of intoxication that could lead if untreated to obstructive acute renal failure. And we recommend to check the overdose symptoms, even those with normal renal function, treated with amantadine.

Is amantadine hard on the kidneys? ›

If you have kidney problems, talk with your doctor. Your dose may need to be changed based on how well your kidneys work. Deaths have happened in people with kidney problems whose dose was too high for Amantadine 3/13 Page 4 their kidney function.

What is the best time of day to take amantadine? ›

Adults—137 milligrams (mg) once a day at bedtime. Your doctor may increase your dose to 274 mg (two 137 mg capsules) once a day at bedtime after one week. Children—Use and dose must be determined by your doctor.

Does amantadine make dogs thirsty? ›

Amantadine also has what are called anticholinergic effects, which include dry mouth (which is seen as increased thirst), retaining urine, and an increased heart rate. These could be problematic when used with medications with similar effects or certain medical conditions.

What is amantadine 100mg used for? ›

AMANTADINE (a MAN ta deen) is an antiviral drug. It is used to prevent and to treat a specific type of flu called influenza A. It will not work for colds, other types of flu, or other viral infections. This drug is also used to treat Parkinson's disease and other movement disorders.

Does amantadine help with walking? ›

Amantadine in clinical trials for MS

Patients improved their walking speed in a timed 25-foot walking test, which measures the time it takes for patients to walk a distance of 25 feet. A Phase 3 ongoing clinical trial (NCT03185065) is testing the effects of commonly used medications to treat fatigue in MS.

What can I give my dog instead of amantadine? ›

There are other oral pain medications that target different pain transmitters and might be helpful in managing your dog's pain.
  • Amantadine. Amantadine blocks NMDA receptors in the spinal cord. ...
  • Gabapentin. ...
  • Lyrica. ...
  • Tramadol. ...
  • Acetaminophen (Tylenol) ...
  • Codeine. ...
  • Amitriptyline.

When should you not use amantadine? ›

Amantadine is contraindicated in patients with hypersensitivity to the drug or components of the formulation. The drug undergoes renal excretion, so the extended-release dosage form is contraindicated in patients with end-stage renal disease.

Why is amantadine not used anymore? ›

Amantadine is no longer recommended for treatment of flu virus in the United States. It was only effective against influenza A viruses, but for several years, these viruses have been resistant to amantadine. This means the drug doesn't work well against these flu viruses.

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